Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-arachidonoylglycerol + H2O | Mus musculus | - |
arachidonoate + glycerol | - |
? | |
2-arachidonoylglycerol + H2O | Mus musculus C57BL/6N | - |
arachidonoate + glycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O35678 | - |
- |
Mus musculus C57BL/6N | O35678 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Mus musculus | - |
embryonic stem cell | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-arachidonoylglycerol + H2O | - |
Mus musculus | arachidonoate + glycerol | - |
? | |
2-arachidonoylglycerol + H2O | - |
Mus musculus C57BL/6N | arachidonoate + glycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MGL | - |
Mus musculus |
MGLL | UniProt | Mus musculus |
monoacylglycerol lipase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | task-specific enhancement of hippocampus-dependent learning occurs in mice deficient in monoacylglycerol lipase. In the object recognition and water-finding tests, MGL KO mice exhibit enhanced memory acquisition. In contrast, in the contextual fear conditioning, MGL KO mice tend to show slower memory extinction. Trace eyeblink conditioning is not altered in MGL KO mice throughout the acquisition and extinction phases. Enhanced visuospatial latent memory in MGL KO mice. Extinction of recognition learning is impaired in MGL KO mice. Behavioral phenotype, detailed overview | Mus musculus |
physiological function | monoacylglycerol lipase is the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. 2-Arachidonoylglycerol (2-AG) signaling is important for hippocampus-dependent learning and memory, but its contribution is highly task-dependent | Mus musculus |